Organisation/Company: Università Cattolica del Sacro Cuore
Research Field: Medical sciences » Medicine
Researcher Profile: Recognised Researcher (R2), Leading Researcher (R4), First Stage Researcher (R1), Established Researcher (R3)
Country: Italy
Application Deadline: 20 Jan 2025 - 23:59 (UTC)
Type of Contract: To be defined
Job Status: Not Applicable
Is the job funded through the EU Research Framework Programme? Other EU programme
Is the Job related to staff position within a Research Infrastructure? No
Offer Description
Fragile X-related Disorders (FXDs) are a group of clinical conditions that primarily result from the CGG expansion at the 5’UTR of the FMR1 gene. Pharmacological approaches based on promising targets failed to show significant clinical benefits illustrating the need for novel therapies. Recent data indicate that mitochondrial function is deranged in FXDs (Nobile et al., 2020; Grandi et al., 2024). These findings are confirmed in preliminary data in iPSCs derived-neurons. Our project aims at clarifying the mitochondrial mechanisms involved in the pathophysiology of FXDs to develop novel treatments.
Eligibility of fellows: country/ies of residence:
* EUROPE
Eligibility of fellows: nationality/ies:
#J-18808-Ljbffr